What is Aspirin?
Miscellanea / / July 04, 2021
The aspirin it's a acetylsalicylic acid o ASA (C9H804), is a salicylate drug that has anti-inflammatory capabilities, reduces mild pain and has been used to thin the blood in patients with myocardial infarction.
The aspirin irritates the stomach in its pure or direct form. When children under 15 years of age consume it during a flu frame, it can cause Reye's syndrome.
It is difficult to find its historical line, until it appears in Egyptian culture. Also the Greeks like Discorides, Galen and Hippocrates, who used the aspirin in its natural form.
In the middle of the 18th century Edgard Stone, who was a reverend of the British church, knowing its medical properties and emphasizing the antipyretic effect reported to Lord Macclesfield, president of the Royal English Society of Science, these properties, using 50 individuals as an example to verify its anti-fever properties by administering it with tea and beer, improving its elevated temperature. Through later work, they came up with the active ingredient they called salicillin, analogous to salicylic acid.
In 1826 the Italians Brugnatelli and Fontana isolated an extract of the plant, but failed to show that the substance caused the known effects of white willow. It is until the year 1828 that Johan Bachner, professor of pharmacy at the University of Munich, isolated a yellowish and bitter substance, which he extracted from crystalline needles which he called salicin. Already in the year 1829 in France, Henri Leroux, achieved an improvised extraction procedure obtaining 30 grams of salicillin from a kilo and a half of bark.
Raffaele Piria, an Italian chemist who worked at the Sorbonne in Paris, managed in 1838 to separate salicin into sugar and an aromatic component called salicylaldehyde. Converting it by hydrolysis and oxidation into colorless crystals calling it salicylic acid.
In 1853 Charles Frédéric Gerhardt was the one who synthesized it and in 1859 Hermann Kolbe synthesized it in the form of salt. It was not until 1897 when the German Felix Hoffmann, from the Bayer house, managed to synthesize it with sufficient purity. Heinrich Dreser in 1899 German pharmacologist described its characteristics, which allowed its sale, thus creating what we know today as the aspirin.